Biology · Module B01

The Cell —
Basic Unit of Life

Every living thing — from a single bacterium to the human body — is made of cells. This module covers everything about cells that appears in CDS, NDA & AFCAT General Science, explained from scratch.

Beginner Friendly CDS · NDA · AFCAT 25 Practice Questions

In this module you will learn: what a cell is, the difference between plant and animal cells, key organelles and their functions, prokaryotes vs eukaryotes, and cell division basics. All of these appear directly in CDS/NDA/AFCAT every year.

Section 1 — What is a Cell?
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Definition & Discovery
Who discovered the cell and why it matters

A cell is the smallest structural and functional unit of all living organisms. It is the basic building block of life — everything a living thing does (breathe, digest, grow, reproduce) happens inside or because of cells.

Think of it this way

If a living body is like a building, then cells are the bricks. Each brick is self-contained, does its job, and together they make the whole structure work.

Discovery Timeline — Frequently Asked
  • Robert Hooke (1665) — first observed cells in a slice of cork using a microscope. Named them "cells" (because they looked like small rooms).
  • Anton van Leeuwenhoek — first observed living cells (bacteria, RBCs, sperm)
  • Schleiden (1838) — all plants are made of cells
  • Schwann (1839) — all animals are made of cells
  • Virchow (1855) — "Omnis cellula e cellula" — every cell comes from a pre-existing cell
  • Cell Theory = Schleiden + Schwann + Virchow together
⚑ Exam Trap

Robert Hooke observed cells in dead cork — not living cells. The first to see living cells was Leeuwenhoek. This distinction is frequently tested.

Section 2 — Prokaryotic vs Eukaryotic Cells
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Two Types of Cells
The most fundamental division in biology

All cells in the world fall into just two categories based on whether they have a proper nucleus or not.

FeatureProkaryoticEukaryotic
NucleusNo true nucleus — DNA floats freely in cytoplasm (nucleoid region)True nucleus enclosed in nuclear membrane
SizeVery small (1–10 µm)Larger (10–100 µm)
Membrane-bound organellesAbsent (no mitochondria, ER, Golgi)Present (mitochondria, ER, Golgi, etc.)
DNA shapeCircular, single chromosomeLinear, multiple chromosomes
Cell wallPresent (made of peptidoglycan)Present in plants (cellulose), fungi (chitin); absent in animals
Ribosomes70S (smaller)80S (larger); 70S in mitochondria/chloroplast
ExamplesBacteria, Cyanobacteria (blue-green algae), MycoplasmaPlants, Animals, Fungi, Protists
⚑ Top Exam Traps
  • Mycoplasma = prokaryote AND the smallest living cell AND has no cell wall
  • Viruses are NOT cells — they are non-cellular (acellular). They have no cytoplasm, no organelles.
  • Mitochondria and chloroplasts have 70S ribosomes (like prokaryotes) — this supports the endosymbiotic theory
  • PPLO (Pleuropneumonia-like organisms) = Mycoplasma = smallest self-replicating organism
Section 3 — Plant Cell vs Animal Cell
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Key Differences
What plant cells have that animal cells don't — and vice versa
FeaturePlant CellAnimal Cell
Cell wallPresent (cellulose)Absent
ChloroplastsPresent (for photosynthesis)Absent
Central vacuoleLarge, single central vacuoleSmall, many or absent
CentriolesAbsent (except lower plants)Present (for cell division)
LysosomesRareCommon ("suicide bags")
PlastidsPresent (chloro-, leuco-, chromo-)Absent
ShapeFixed, rectangular (due to cell wall)Irregular, flexible
Glycogen storageAbsent (stores starch)Present
Memory Trick — What Only PLANTS Have
  • Cell wall · Chloroplasts · Central vacuole · Plastids = "Plants have 3 Cs and P"
Memory Trick — What Only ANIMALS Have
  • Centrioles · Lysosomes · Glycogen = "Animals have CLG"
Section 4 — Cell Organelles & Their Functions
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Cell Membrane & Cell Wall
The outer boundary of every cell

Every cell is surrounded by a cell membrane (also called plasma membrane). In plant cells, there is also a stiff cell wall outside the membrane.

Cell MembraneCell Wall
Present inALL cells (plant + animal)Plants, Fungi, Bacteria (not animals)
Made ofPhospholipid bilayer + proteins (Fluid Mosaic Model)Cellulose (plants) · Chitin (fungi) · Peptidoglycan (bacteria)
FunctionControls what enters and exits the cell (selectively permeable)Provides shape, rigidity, protection
Fluid Mosaic Model — Singer & Nicolson (1972)

The cell membrane is described as a fluid mosaic — "fluid" because the phospholipid molecules can move around, and "mosaic" because proteins are scattered throughout like tiles in a mosaic. This is the accepted model for all cell membranes.

⚑ Exam Trap

The cell membrane is selectively permeable (lets some things in, blocks others). It is NOT fully permeable or fully impermeable. This exact phrase — "selectively permeable" — is tested directly.

Mitochondria
Powerhouse of the cell

Mitochondria are the sites of cellular respiration — they convert food (glucose) into energy in the form of ATP (Adenosine Triphosphate).

Simple Analogy

Mitochondria are like the power plant of a city. The city (cell) needs electricity (ATP) to function. The power plant burns fuel (glucose) and generates the electricity.

Key Facts — Very Frequently Asked
  • Called the "Powerhouse of the cell"
  • Has a double membrane — outer membrane (smooth) + inner membrane (folded into cristae)
  • The inner fluid is called matrix
  • Has its own DNA and ribosomes (70S) — can self-replicate (semi-autonomous)
  • ATP = energy currency of the cell
  • Present in ALL eukaryotic cells except RBCs (Red Blood Cells in humans)
  • Most mitochondria found in cells with high energy demand — liver, muscle, heart
⚑ Exam Trap

Human Red Blood Cells (RBCs) have NO mitochondria and no nucleus. They rely entirely on anaerobic respiration (glycolysis) for energy. This is a very common question in CDS/NDA.

☀️
Chloroplast
The kitchen of the plant cell

Chloroplasts are found only in plant cells and some algae. They contain chlorophyll — the green pigment that traps sunlight and uses it to make food through photosynthesis.

Key Facts
  • Contains green pigment chlorophyll (gives plants their colour)
  • Has a double membrane, like mitochondria
  • Internal membrane system = thylakoids (stacked into grana)
  • Inner fluid = stroma (where Calvin cycle happens)
  • Has its own DNA and 70S ribosomes — semi-autonomous
  • Site of photosynthesis: CO₂ + H₂O + sunlight → glucose + O₂
Types of Plastids
  • Chloroplasts — green, contain chlorophyll, photosynthesis
  • Chromoplasts — coloured (red, orange, yellow) — give colour to fruits and flowers
  • Leucoplasts — colourless — store starch, oils, proteins (e.g. in potato, seeds)
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All Other Key Organelles
Nucleus, ER, Golgi, Ribosomes, Lysosomes, Vacuole
🧠 Nucleus Control Centre

Brain of the cell. Contains DNA (genetic material). Surrounded by nuclear envelope with pores. Contains nucleolus (makes ribosomes). Controls all cell activities.

🏗️ Ribosome Protein Factory

Site of protein synthesis. No membrane. Two types: 70S (prokaryotes, mitochondria, chloroplasts) and 80S (eukaryote cytoplasm). Discovered by George Palade.

🛣️ Endoplasmic Reticulum Transport Network

Rough ER (has ribosomes) — makes proteins. Smooth ER (no ribosomes) — makes lipids, detoxifies. Forms a network of channels throughout the cell.

📮 Golgi Apparatus Post Office

Packages and ships proteins made by ribosomes. Modifies, sorts, and sends materials to correct destinations inside or outside the cell. Also makes lysosomes.

💣 Lysosome Suicide Bag

Contains digestive enzymes. Breaks down worn-out organelles, bacteria, and dead cells (autophagy). If lysosome bursts — the cell self-destructs. Found mainly in animal cells.

💧 Vacuole Storage Tank

Stores water, sap, waste. Plant cells have ONE large central vacuole (maintains cell turgidity). Animal cells have several small vacuoles or none.

🌀 Centrosome Division Helper

Contains centrioles. Forms the spindle fibres during cell division. Present in animal cells. Absent in higher plant cells. Made of microtubules arranged in 9+0 pattern.

🔋 Peroxisome

Breaks down fatty acids and amino acids. Neutralises toxic hydrogen peroxide (H₂O₂) using catalase enzyme. Important in liver and kidney cells.

⚑ Nicknames That Are Directly Asked
  • Mitochondria = Powerhouse of the cell
  • Nucleus = Control centre / Brain of the cell
  • Ribosome = Protein factory
  • Lysosome = Suicide bag (autolysis)
  • Golgi apparatus = Post office / Traffic police of the cell
  • Cell membrane = Selectively permeable membrane
  • Chloroplast = Kitchen of the cell
Section 5 — Cell Division
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Mitosis & Meiosis
Two types of cell division — how and where each occurs

Cells reproduce by dividing. There are two types of division, and they serve completely different purposes.

FeatureMitosisMeiosis
Also calledEquational divisionReductional division
DivisionsOne divisionTwo divisions (Meiosis I + II)
Daughter cells produced2 daughter cells4 daughter cells
Chromosome numberSame as parent (diploid → diploid)Half of parent (diploid → haploid)
Where it occursBody (somatic) cells — skin, liver, bonesReproductive cells — testes, ovary
PurposeGrowth, repair, replacement of cellsFormation of gametes (sperm and eggs)
Genetic variationNo — daughter cells identical to parentYes — crossing over creates variation
Stages of Mitosis — PMAT
  • Prophase — chromosomes condense, nuclear envelope breaks down
  • Metaphase — chromosomes line up at centre (equatorial plate)
  • Anaphase — sister chromatids pulled to opposite poles
  • Telophase — nuclear envelopes reform, cell pinches
  • Before all this: Interphase — DNA replication (S phase)
⚑ Exam Traps
  • Mitosis in a human cell produces 2 cells each with 46 chromosomes
  • Meiosis produces 4 cells each with 23 chromosomes (haploid)
  • Cancer = uncontrolled mitosis
  • DNA replication occurs in Interphase (S phase) — NOT during mitosis itself
  • Chromosomes are most visible (most condensed) during Metaphase
Section 6 — Special Cell Facts
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High-Yield Facts for Exam
These facts appear almost every year
Must-Know Cell Facts
  • Largest cell in the human body = Ovum (egg cell)
  • Longest cell in the human body = Neuron (nerve cell)
  • Smallest cell = Mycoplasma (PPLO)
  • Largest cell in nature = Ostrich egg
  • Most abundant cell in human blood = RBC (Red Blood Cell)
  • Human RBC has NO nucleus and NO mitochondria — survives ~120 days
  • Nerve cells (neurons) do NOT divide (no mitosis after birth in most neurons)
  • Totipotent cells = can become any cell type (embryonic stem cells)
  • A typical human body has about 37 trillion cells
  • Water = most abundant molecule in a cell (~70%)
⚑ Most Common Traps
  • RBC has no nucleus — so it cannot divide and cannot make new proteins
  • Viruses are non-cellular — they are NOT made of cells. They need a host cell to replicate.
  • The cell theory does NOT apply to viruses
  • Largest human cell = Ovum · Longest human cell = Neuron (these are different questions!)

All the high-yield facts from this module in one place. Scan this page before your exam.

Cell Discovery
  • Robert Hooke (1665) — discovered cell in dead cork
  • Leeuwenhoek — first saw living cells
  • Schleiden (1838) — plants made of cells
  • Schwann (1839) — animals made of cells
  • Virchow (1855) — cells from pre-existing cells
  • Cell theory = Schleiden + Schwann + Virchow
  • Viruses = NOT cells — acellular
Prokaryote vs Eukaryote
  • Prokaryote = no true nucleus, no membrane-bound organelles
  • Bacteria, Cyanobacteria = prokaryotes
  • Eukaryote = true nucleus, all organelles
  • Mycoplasma = smallest living cell, no cell wall
  • Prokaryote ribosomes = 70S
  • Eukaryote ribosomes = 80S (70S in mitochondria)
  • Viruses = acellular (not prokaryote or eukaryote)
Plant vs Animal Cell
  • Only plant: Cell wall, Chloroplast, Central vacuole, Plastids
  • Only animal: Centrioles, Lysosomes, Glycogen
  • Cell wall = cellulose (plant) · chitin (fungi)
  • Plant stores starch · Animal stores glycogen
  • Fluid Mosaic Model = Singer & Nicolson 1972
  • Cell membrane = selectively permeable
Organelle Nicknames
  • Mitochondria = Powerhouse of the cell
  • Nucleus = Control centre / Brain
  • Ribosome = Protein factory
  • Lysosome = Suicide bag
  • Golgi body = Post office / Traffic police
  • Chloroplast = Kitchen of the cell
  • Vacuole = Storage tank
Mitochondria Facts
  • Double membrane — outer smooth, inner cristae
  • Inner fluid = matrix
  • Has own DNA + 70S ribosomes
  • Makes ATP — energy currency of cell
  • Absent in human RBCs
  • Most in liver, muscle, heart cells
  • Semi-autonomous organelle
Mitosis vs Meiosis
  • Mitosis = 2 cells, same chromosomes, somatic cells
  • Meiosis = 4 cells, half chromosomes, sex cells
  • Mitosis stages: PMAT (Prophase, Metaphase, Anaphase, Telophase)
  • DNA replication = Interphase (S phase)
  • Chromosomes most visible = Metaphase
  • Cancer = uncontrolled mitosis
Special Cell Facts
  • Largest human cell = Ovum
  • Longest human cell = Neuron
  • Smallest cell = Mycoplasma
  • Largest cell in nature = Ostrich egg
  • RBC = no nucleus, no mitochondria, lives ~120 days
  • Neurons = do NOT divide after birth
  • Water = most abundant molecule in cell (~70%)
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